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Modulation of orbitofrontal response to amphetamine by a functional variant of DAT1 and in vitro confirmation

Molecular Psychiatry volume 16, pages 124–126 (2011)Cite this article

Subjects

Dopamine plays a key role in the reward pathways within the brain. The plasma membrane dopamine transporter (DAT1) is found exclusively in dopamine neurones and regulates the reuptake of dopamine from the synapse.1 A recently discovered polymorphism, allele 3 of the variable number tandem repeat in intron 8 (Int8 VNTR), has been linked with an increased propensity to abuse cocaine.2 However, it is not clear how this allele influences the cortical substrate underlying reward processing. We describe the effects of a functional genetic variant in DAT1 on cortical activation during a functional magnetic resonance imaging study of reward processing in subjects treated with amphetamine.

All subjects were given £15 at the start of the experiment, and required to risk £1 on each subsequent gambling trial. Each trial consisted of a spinning roulette wheel, and the participants were cued to select one of two colours. The subjects total balance was updated with the win or losses.

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Authors and Affiliations

  1. Department of Psychiatry, Clinic Hospital, Valencia, Spain

    O Brotons & S S Shergill

  2. CIBER Mental Health Network, Valencia, Spain

    O Brotons

  3. King's College London, Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK

    O G O'Daly, G Barker & J Dalton

  4. King's College London, MRC Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK

    C Guindalini & G Breen

  5. Department of Psychiatry, Clinical Neuroscience Laboratory, Federal University of São Paulo, Rua Botucatu, Brazil

    C Guindalini

  6. Department of Psychobiology, Federal University of São Paulo, Rua Botucatu, Brazil

    C Guindalini

  7. Department of Psychiatry, University of São Paulo, Medical School, Rua Botucatu, Brazil

    C Guindalini

  8. Divisions of Physiology and Human Anatomy Cell Biology, Neurotransmitter Research Group, School of Biomedical Sciences, University of Liverpool, Merseyside, UK

    M Howard, J Bubb & J Quinn

  9. King's College London, Psychological Medicine and Psychiatry, Institute of Psychiatry, London, UK

    R M Murray

  10. King's College London, NIHR Biomedical Research Centre for Mental Health, Institute of Psychiatry and South London and Maudsley NHS Trust, London, UK

    G Breen

  11. King's College London, Cognition Schizophrenia and Imaging Laboratory, Psychological Medicine and Psychiatry, Institute of Psychiatry, London, UK

    S S Shergill

Authors
  1. O Brotons
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  2. O G O'Daly
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  3. C Guindalini
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  7. J Dalton
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  10. G Breen
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  11. S S Shergill
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Corresponding author

Correspondence to G Breen.

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Brotons, O., O'Daly, O., Guindalini, C. et al. Modulation of orbitofrontal response to amphetamine by a functional variant of DAT1 and in vitro confirmation. Mol Psychiatry 16, 124–126 (2011). https://doi.org/10.1038/mp.2009.6

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