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A community-based model of rapid autopsy in end-stage cancer patients

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Figure 1
Figure 2: Tumor-type-specific immunohistochemistry of post-mortem CASCADE samples.

References

  1. Collins, F.S. & Barker, A.D. Sci. Am. 296, 50–57 (2007).

    Article  CAS  Google Scholar 

  2. Hudson, T.J. et al. Nature 464, 993–998 (2010).

    Article  CAS  Google Scholar 

  3. Gerlinger, M. et al. N. Engl. J. Med. 366, 883–892 (2012).

    Article  CAS  Google Scholar 

  4. Andersson, A.K. et al. Nat. Genet. 47, 330–337 (2015).

    Article  CAS  Google Scholar 

  5. Keats, J.J. et al. Blood 120, 1067–1076 (2012).

    Article  CAS  Google Scholar 

  6. van Thuijl, H.F. et al. Acta Neuropathol. 129, 597–607 (2015).

    Article  CAS  Google Scholar 

  7. Patch, A.M. et al. Nature 521, 489–494 (2015).

    Article  CAS  Google Scholar 

  8. Topp, M.D. et al. Mol. Oncol. 8, 656–668 (2014).

    Article  Google Scholar 

  9. Quintana, E. et al. Cancer Cell 18, 510–523 (2010).

    Article  CAS  Google Scholar 

  10. Read, M. et al. Ann. Surg. Oncol. 23, 305–311 (2016).

    Article  Google Scholar 

  11. Lawrence, M.G. et al. Nat. Protoc. 8, 836–848 (2013).

    Article  CAS  Google Scholar 

  12. Laidlaw, I.J. et al. Endocrinology 136, 164–171 (1995).

    Article  CAS  Google Scholar 

  13. van der Linden, A. et al. PLoS One 9, e115675 (2014).

    Article  Google Scholar 

  14. Pentz, R.D. et al. Nat. Med. 11, 1145–1149 (2005).

    Article  CAS  Google Scholar 

  15. Lindell, K.O., Erlen, J.A. & Kaminski, N. PLoS Med. 3, e234 (2006).

    Article  Google Scholar 

  16. Steinhauser, K.E. et al. Ann. Intern. Med. 132, 825–832 (2000).

    Article  CAS  Google Scholar 

  17. Dedova, I. et al. Int. J. Mol. Sci. 10, 366–384 (2009).

    Article  CAS  Google Scholar 

  18. Gundem, G. et al. Nature 520, 353–357 (2015).

    Article  CAS  Google Scholar 

  19. Campbell, P.J. et al. Nature 467, 1109–1113 (2010).

    Article  CAS  Google Scholar 

  20. Shah, S.P. et al. Nature 461, 809–813 (2009).

    Article  CAS  Google Scholar 

  21. Krøigård, A.B. et al. Oncotarget 6, 5634–5649 (2015).

    Article  Google Scholar 

  22. Cassidy, J.W., Caldas, C. & Bruna, A. Cancer Res. 75, 2963–2968 (2015).

    Article  CAS  Google Scholar 

  23. Eirew, P. et al. Nature 518, 422–426 (2015).

    Article  CAS  Google Scholar 

  24. Hulette, C.M. J. Neuropathol. Exp. Neurol. 62, 715–722 (2003).

    Article  Google Scholar 

  25. Kretzschmar, H. Nat. Rev. Neurosci. 10, 70–78 (2009).

    Article  CAS  Google Scholar 

  26. Embuscado, E.E. et al. Cancer Biol. Ther. 4, 548–554 (2005).

    Article  CAS  Google Scholar 

  27. Rubin, M.A. et al. Clin. Cancer Res. 6, 1038–1045 (2000).

    CAS  PubMed  Google Scholar 

  28. Beach, T.G. et al. Neuropathology 35, 354–389 (2015).

    Article  Google Scholar 

  29. Carithers, L.J. et al. Biopreserv. Biobank. 13, 311–319 (2015).

    Article  Google Scholar 

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Acknowledgements

The CASCADE program was funded initially by a grant from the Peter MacCallum Cancer Foundation. The CASCADE investigators would like to acknowledge the support and guidance of the CASCADE Management Committee. kConFab wishes to thank E. Niedermayr, all the kConFab research nurses and staff, the heads and staff of Family Cancer Clinics and the Clinical Follow Up Study (which has received funding from the NHMRC, the National Breast Cancer Foundation, Cancer Australia and the US National Institutes of Health) for contributions to this resource, and the many families who contribute to kConFab. We sincerely thank the hospital and hospice staff involved in the care of CASCADE participants, the staff at Tobin Brothers Funerals, the Victorian Institute of Forensic Medicine and the participants and their family members. This work was supported by the Peter MacCallum Cancer Foundation; the National Health and Medical Research Council (APP631701 and APP1092856 to D.B., APP1035721 to M.G.L; APP1002648 to G.P.R., APP1035298 to C.F., APP628735 to M.S., APP1054618 to A.P, and APP1062702 to C.S.) to Ovarian Cancer Australia to D.B., the Victorian Cancer Agency (EOI09_27 and CRF13026 (clinical research fellowship to L.M.)); the National Breast Cancer Foundation of Australia (14-067, Infrastructure Grant (kConFab)); the Cancer of the Prostate Translational Research in Victoria (CAPTIV) Collaboration; Amgen (S.S.); the Peter and Lyndy White Foundation; the ANZ Trustees; the Queensland Cancer Fund; the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia; the Cancer Foundation of Western Australia; Prostate Cancer Foundation of Australia (Movember Young Investigator grant to M.G.L.); Pfizer Australia; the Victorian Endowment for Science, Knowledge and Innovation (M.S.); the Lorenzo and Pamela Galli Charitable Trust; the Cancer Council Victoria Sir Edward Dunlop Fellowship in Cancer Research (CS); CRC for Cancer Therapeutics (M.T.) and the Stafford Fox Medical Research Foundation. Work performed by C.S. was made possible through Victorian State Government Operational Infrastructure Support, Australian Government NHMRC IRIISS and the Australian Cancer Research Foundation.

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Alsop, K., Thorne, H., Sandhu, S. et al. A community-based model of rapid autopsy in end-stage cancer patients. Nat Biotechnol 34, 1010–1014 (2016). https://doi.org/10.1038/nbt.3674

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