Mitotic chromosome condensation has fascinated biologists since Flemming's early illustrations of mitosis in the late nineteenth century. Now — 130 years later — chromatid condensation is reconstituted in vitro with the minimum components. The results are remarkably and beautifully simple, requiring only core histones, three histone chaperones, topoisomerase II and condensin I.
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Bell, J., Straight, A. Condensing chromosome condensation. Nat Cell Biol 17, 964–965 (2015). https://doi.org/10.1038/ncb3212
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DOI: https://doi.org/10.1038/ncb3212
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