Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Assignment by Deletion of Human Red Cell Acid Phosphatase Gene Locus to the Short Arm of Chromosome 2

Nature New Biology volume 243, pages 271–274 (1973)Cite this article

Abstract

DEVELOPMENT malformations associated with gross chromosomal deletions are well known in man. Those cases in which the extent of the deletion can be defined accurately by chromosome banding techniques should provide an opportunity for identifying some of the gene loci located within the deleted segment. But the positive assignment of a gene locus to a particular region in the human karyotype does not seem to have been achieved by this method. In several promising cases, the coincidence of a deletion and the familial segregation of an undetectable or “silent” allele has raised false hopes1.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Renwick, J. H., Ann. Rev. Genet., 5, 81 (1971).

    Article  CAS  Google Scholar 

  2. Seabright, M., Chromosoma, Berl., 36, 204 (1972).

    Article  CAS  Google Scholar 

  3. Paris Conf. (1971): Standardization in Human Cytogenetics. Birth Defects, Original Article Series, VIII (The National Foundation, New York, 1972).

  4. Race, R. R., and Sanger, R., Blood Groups in Man (fifth ed.) (Blackwell, Oxford, 1968).

    Google Scholar 

  5. Giblett, E. R., Genetic Markers in Human Blood (Blackwell, Oxford, 1969).

  6. Hopkinson, D. A., Spencer, N., and Harris, H., Amer. J. Hum. Genet., 16, 141 (1964).

    CAS  PubMed  Google Scholar 

  7. Herbich, J., Fisher, R. A., and Hopkinson, D. A., Ann. Hum. Genet., Lond., 34, 145 (1970).

    Article  CAS  Google Scholar 

  8. Herbich, J., and Meinhart, K., Humangenetik, 15, 345 (1972).

    CAS  PubMed  Google Scholar 

  9. Spencer, N., Hopkinson, D. A., and Harris, H., Nature, 201, 299 (1964).

    Article  CAS  Google Scholar 

  10. Weitkamp, L. R., Janzen, M. K., Guttormsen, S. A., and Gershowitz, H., Ann. Hum. Genet., Lond., 33, 53 (1969).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Genetics and Child Health, University of Glasgow,

    M. A. FERGUSON-SMITH, BRIONY F. NEWMAN, PATRICIA M. ELLIS & DIANE M. G. THOMSON

  2. Department of Medical Paediatrics, Stobhill General Hospital, Glasgow

    I. D. RILEY

Authors
  1. M. A. FERGUSON-SMITH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. BRIONY F. NEWMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. PATRICIA M. ELLIS
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. DIANE M. G. THOMSON
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. D. RILEY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

FERGUSON-SMITH, M., NEWMAN, B., ELLIS, P. et al. Assignment by Deletion of Human Red Cell Acid Phosphatase Gene Locus to the Short Arm of Chromosome 2. Nature New Biology 243, 271–274 (1973). https://doi.org/10.1038/newbio243271a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio243271a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing