Natural killer T cells (NKT cells) recognize lipid-based antigens presented by CD1d. The mammalian glycolipid β-glucosylceramide, a ubiquitous self antigen for NKT cells, is upregulated by microbial danger signals, which leads to activation of NKT cells in the absence of foreign glycolipid antigen.
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Godfrey, D., Pellicci, D. & Rossjohn, J. Beta-testing NKT cell self-reactivity. Nat Immunol 12, 1135–1137 (2011). https://doi.org/10.1038/ni.2162
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DOI: https://doi.org/10.1038/ni.2162
