B cell–T cell interactions in germinal centers are needed to generate high-affinity antibodies. PD-1 signaling is now shown to influence the quality of germinal center responses.
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Nutt, S., Tarlinton, D. Give and take in the germinal center. Nat Immunol 11, 464–466 (2010). https://doi.org/10.1038/ni0610-464
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DOI: https://doi.org/10.1038/ni0610-464
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