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CD1d antigen presentation: treats for NKT cells

Structural studies of CD1d presentation of α-galactosylceramide have shown that the lipid component fits snugly in the cleft, whereas the galactosyl head group protrudes upward, with key contact points between CD1d and the antigen conserved between mouse and human structures.

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Figure 1: Conserved antigen recognition by NKT cells despite species polymorphism in the presentation of α-GalCer by human and mouse CD1d.

Katie Ris

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Godfrey, D., McCluskey, J. & Rossjohn, J. CD1d antigen presentation: treats for NKT cells. Nat Immunol 6, 754–756 (2005). https://doi.org/10.1038/ni0805-754

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