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Rebuilding Humpty Dumpty with a serotonin inhibitor

Nature Medicine volume 16, pages 264–265 (2010)Cite this article

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An Erratum to this article was published on 01 May 2010

This article has been updated

Serotonin produced in the gut reduces the formation of bone. This biology is now harnessed with an orally available inhibitor of gut serotonin synthesis (pages 308–312). The inhibitor promotes bone formation in rodents and points the way to the development of much-needed bone-building drugs.

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Change history

  • 01 April 2010

     In the version of this article initially published, several articles were eliminated from the reference list during layout, and several typographical errors were introduced. These errors have been corrected in the HTML and PDF versions of the article.

References

  1. Parfitt, A.M. in Osteoporosis. (eds. Marcus, R., Feldman, D. & Kelsey, J.) 315–339 (Academic, San Diego, 1996).

    Google Scholar 

  2. Seeman, E. & Delmas, P.D. N. Engl. J. Med. 354, 2250–2261 (2006).

    Article  CAS  Google Scholar 

  3. Delmas, P.D. Lancet 359, 2018–2026 (2002).

    Article  CAS  Google Scholar 

  4. Frolik, C.A. et al. Bone 33, 372–379 (2003).

    Article  CAS  Google Scholar 

  5. Confavreux, C.B., Levinea, R.L. & Karsenty, G Mol. Cell. Endocrinol. 310, 21–29 (2009).

    Article  CAS  Google Scholar 

  6. Yadav, V.K. et al. Cell 138, 976–989 (2009).

    Article  CAS  Google Scholar 

  7. Baron, R. & Rawadi, G Endocrinology 148, 2635–2643 (2007).

    Article  CAS  Google Scholar 

  8. Yadav, V.K. et al. Nat. Med. 16, 308–312 (2010).

    Article  CAS  Google Scholar 

  9. Ducy, P. et al. Cell 100, 197–207 (2000).

    Article  CAS  Google Scholar 

  10. Lee, N.K. et al. Cell 130, 456–469 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Ego Seeman is in the Department of Endocrinology and Medicine, Austin Health, University of Melbourne, Melbourne, Australia.,

    Ego Seeman

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  1. Ego Seeman
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Correspondence to Ego Seeman.

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The author declares no competing financial interests.

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Seeman, E. Rebuilding Humpty Dumpty with a serotonin inhibitor. Nat Med 16, 264–265 (2010). https://doi.org/10.1038/nm0310-264

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