Accumulating evidence from several studies points to the normal function of presenilin 1 and suggests how the mutant protein contributes to deposition of amyloid plaques in Alzheimer's disease (pages 756–760).
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Beyreuther, K., Masters, C. Serpents on the road to dementia and death. Nat Med 3, 723–725 (1997). https://doi.org/10.1038/nm0797-723
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DOI: https://doi.org/10.1038/nm0797-723