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Simplifying complexity

A software tool based on gene model profiling improves analysis of alternative splice events in RNA sequencing (RNA-seq) data.

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Figure 1: Three models of transcriptome reconstruction.

References

  1. Griffith, M. et al. Nat. Methods 7, 843–847 (2010).

    Article  CAS  Google Scholar 

  2. Carninci, P. et al. Science 309, 1559–1563 (2005).

    Article  CAS  Google Scholar 

  3. Cloonan, N. et al. Nat. Methods 5, 613–619 (2008).

    Article  CAS  Google Scholar 

  4. Mortazavi, A., Williams, B.A., McCue, K., Schaeffer, L. & Wold, B. Nat. Methods 5, 621–628 (2008).

    Article  CAS  Google Scholar 

  5. Birol, I. et al. Bioinformatics 25, 2872–2877 (2009).

    Article  CAS  Google Scholar 

  6. Zerbino, D.R. & Birney, E. Genome Res. 18, 821–829 (2008).

    Article  CAS  Google Scholar 

  7. Guttman, M. et al. Nat. Biotechnol. 28, 503–510 (2010).

    Article  CAS  Google Scholar 

  8. Trapnell, C. et al. Nat. Biotechnol. 28, 511–515 (2010).

    Article  CAS  Google Scholar 

  9. Reimers, M. & Carey, V.J. Methods Enzymol. 411, 119–134 (2006).

    Article  CAS  Google Scholar 

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Correspondence to Nicole Cloonan.

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Cloonan, N., Grimmond, S. Simplifying complexity. Nat Methods 7, 793–795 (2010). https://doi.org/10.1038/nmeth1010-793

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