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Gene delivery

Cell-specific therapy on target

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A polymer–lipid nanoparticle with a low molecular weight can preferentially deliver small interfering RNA to endothelial cells, offering an opportunity to treat many diseases.

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Figure 1: Small, multilamellar 7C1 nanoformulations selectively deliver siRNA to endothelial cells in vivo.

References

  1. Tabernero, J. et al. Cancer Discovery 3, 406–417 (2013).

    Article  CAS  Google Scholar 

  2. Kanasty, R. et al. Nature Mater. 12, 967–977 (2013).

    Article  CAS  Google Scholar 

  3. Coelho, T. et al. N. Engl. J. Med. 369, 819–829 (2013).

    Article  CAS  Google Scholar 

  4. Dahlman, J. E. et al. Nature Nanotech. 9, 648–655 (2014).

    Article  CAS  Google Scholar 

  5. Ganesh, S. et al. J. Control. Release 172, 699–706 (2013).

    Article  CAS  Google Scholar 

  6. Fitzgerald, K. et al. Lancet 383, 60–68 (2014).

    Article  CAS  Google Scholar 

  7. Kumar, V. et al. in Robbins and Cotran Pathologic Basis of Disease 8th edn (eds Schmitt, W. & Gruliow, R.) Ch. 11 (Saunders-Elsevier, 2009).

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Correspondence to Nigel A. J. McMillan.

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Clarke, D., McMillan, N. Cell-specific therapy on target. Nature Nanotech 9, 568–569 (2014). https://doi.org/10.1038/nnano.2014.155

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