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  • Opinion
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Towards an HIV cure: a global scientific strategy

Abstract

Given the limitations of antiretroviral therapy and recent advances in our understanding of HIV persistence during effective treatment, there is a growing recognition that a cure for HIV infection is both needed and feasible. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. Several priorities for basic, translational and clinical research were identified. This Opinion article summarizes the group's recommended key goals for the international community.

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Figure 1: The impact of antiretroviral therapy on HIV reservoirs.
Figure 2: Mechanisms of HIV persistence during antiretroviral therapy.

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Acknowledgements

The International AIDS Society and the Scientific Working Group 'Towards an HIV Cure' acknowledge the fruitful input received from the members of the 'Towards an HIV Cure' Advisory Board, the members of the Working Group on Ethical Issues and the participants of the Stakeholders' Consultations. The full list of contributors can be found on the International AIDS Society website. The Global Scientific Strategy 'Towards an HIV Cure' is a project of the International AIDS Society in partnership with the French National Agency for Research on AIDS and Viral Hepatitis, the US National Institutes of Health, Sidaction and the Treatment Action Group. Stakeholders' Consultations have been organized in partnership with the Australasian Society for HIV Medicine, the European AIDS Treatment Group, the European AIDS Clinical Society and the US National Alliance of State and Territorial AIDS Directors. The authors would like to thank M. Eckert, B. Kadasia, R. Lamplough, S. Heidari, T. Torri and Y. Mameletzis from the International AIDS Society as well as O. Rescanière from the Institut Pasteur for their support in facilitating the development of the scientific strategy.

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Correspondence to Steven G. Deeks.

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The International AIDS Society Scientific Working Group on HIV Cure. Towards an HIV cure: a global scientific strategy. Nat Rev Immunol 12, 607–614 (2012). https://doi.org/10.1038/nri3262

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