The past decade has seen developments in several aspects of acute kidney injury (AKI), including the discovery of an array of biomarkers, assessment of the optimal dose intensity for renal replacement therapy, and the impact of fluid administration. Furthermore, AKI has emerged as an important risk factor for chronic kidney disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mishra, J. et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365, 1231–1238 (2005).
Kashani, K. et al. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit. Care 17, R25 (2013).
VA/NIH Acute Renal Failure Trial Network. Intensity of renal support in critically ill patients with acute kidney injury. N. Engl. J. Med. 359, 7–20 (2005).
The RENAL Replacement Therapy Study Investigators. Intensity of continuous renal replacement therapy in critically ill patients. N. Engl. J. Med. 361, 1627–1638 (2009).
Ronco, C. et al. Cardiorenal syndrome. J. Am. Coll. Cardiol. 52, 1527–1539 (2008).
Sutherland, S. M. et al. Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am. J. Kidney Dis. 55, 316–325 (2010).
KDIGO working group. KDIGO clinical practice guidelines for acute kidney injury. Kidney Int. Suppl. 2, 1–136 (2012).
Perner, A. et al. Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N. Engl. J. Med. 367, 124–134 (2012).
Myburgh, J. A. et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N. Engl. J. Med. 367, 1901–1911 (2012).
Wald. R. et al. Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. JAMA 302, 1179–1185 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
R.B. has received grants from Baxter and honoraria from Gambro and B. Braun.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Bellomo, R. Acute kidney injury—a decade of progress. Nat Rev Nephrol 11, 636–637 (2015). https://doi.org/10.1038/nrneph.2015.147
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2015.147
