Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Year in Review
  • Published:

Epilepsy in 2014

Novel and large collaborations drive advances in epilepsy

Nature Reviews Neurology volume 11, pages 74–76 (2015)Cite this article

Subjects

In 2014, novel, large-scale collaborative efforts and frameworks resulted in major advances in the epilepsy field, from publication of a new definition of epilepsy to important discoveries regarding aetiology, pathophysiology and management. These collaborative works provide a platform from which further advances are anticipated, and a model for future research.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Fisher, R. S. et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia 55, 475–482 (2014).

    Article  PubMed  Google Scholar 

  2. Fisher, R. S. et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 46, 470–472 (2005).

    Article  PubMed  Google Scholar 

  3. Shinnar, S. in Febrile Seizures (eds Baram, T. Z. & Shinnar, S.) 87–101 (Academic Press, 2002).

    Book  Google Scholar 

  4. Lewis, D. V. et al. Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study. Ann. Neurol. 75, 178–185 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Thomas, R. H. & Berkovic, S. F. The hidden genetics of epilepsy—a clinically important new paradigm. Nat. Rev. Neurol. 10, 283–292 (2014).

    Article  PubMed  Google Scholar 

  6. International League Against Epilepsy Consortium on Complex Epilepsies. Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. Lancet Neurol. 13, 893–903 (2014).

  7. Poduri, A., Evrony, G. D., Cai, X. & Walsh, C. A. Somatic mutation, genomic variation, and neurological disease. Science 341, 1237758 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Jamuar, S. S. et al. Somatic mutations in cerebral cortical malformations. N. Engl. J. Med. 371, 733–743 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Meador, K. J. et al. Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at age 6 years. JAMA Pediatr. 168, 729–736 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Bech, B. H. et al. Use of antiepileptic drugs during pregnancy and risk of spontaneous abortion and stillbirth: population based cohort study. BMJ 349, g5159 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Neurology, The Royal Melbourne Hospital, The University of Melbourne, 4th Floor Clinical Sciences Building, Royal Parade, Parkville, 3050, Vic, Australia

    Piero Perucca & Terence J. O'Brien

Authors
  1. Piero Perucca
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Terence J. O'Brien
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Terence J. O'Brien.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Perucca, P., O'Brien, T. Novel and large collaborations drive advances in epilepsy. Nat Rev Neurol 11, 74–76 (2015). https://doi.org/10.1038/nrneurol.2014.255

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2014.255

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing