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Important factors in implementation of lineage-specific chimerism analysis for routine use

Bone Marrow Transplantation volume 56, pages 946–948 (2021)Cite this article

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To the Editor:

Monitoring of donor-specific chimerism is universally recognised as essential in the follow-up of patients after allogeneic haemopoietic stem cell transplantation. Lineage-specific chimerism testing can provide an early indication of disease relapse and risk assessment of impending graft failure [1,2,3]. This early molecular detection method may allow adequate time to evaluate a patient’s clinical status, and assist in determining the need for immediate interventions to improve outcomes.

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Acknowledgements

We are grateful to Catherine O’Dwyer for guidance on quality controls and accredited requirements, and thanks to the transplantation team at the Alfred Hospital.

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Authors and Affiliations

  1. Malignant Haematology and Stem Cell Transplantation Service, Department of Clinical Haematology, The Alfred Hospital, Melbourne, VIC, Australia

    Tongted P. Das, David S. Kliman, Sushrut S. Patil, David J. Curtis, Maureen E. O’Brien, Michael I. Swain, Jacqueline M. L. Widjaja & Andrew Spencer

  2. Epworth Geelong Hospital, Geelong, VIC, Australia

    David A. Kipp

  3. Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia

    David J. Curtis & Andrew Spencer

  4. Australian Genome Research Facility, Melbourne, VIC, Australia

    Jade L. Cooke & Melinda N. Ziino

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  1. Tongted P. Das
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Correspondence to Tongted P. Das.

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Das, T.P., Kipp, D.A., Kliman, D.S. et al. Important factors in implementation of lineage-specific chimerism analysis for routine use. Bone Marrow Transplant 56, 946–948 (2021). https://doi.org/10.1038/s41409-020-01089-6

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