The incidence of unexplained central vision loss immediately following removal of silicone oil (ROSO) has been reported at between 3.3% [1] and 5.9% [2], but may be considerably higher in certain retinal detachment sub-groups. For example, the rate of ROSO maculopathy after macula-on giant retinal tear (GRT) repair was reported as high as 50% [1] in this journal, perhaps suggesting macula-on GRTs (Fig 1), or indeed any macula-on retinal detachment, are uniquely susceptible to ROSO maculopathy.
Perfluorocarbon heavy liquid (PFCL) as a short-term post-operative tamponade agent in GRT repair is a safe and effective alternative to silicone oil (SiO) or gas. This technique, first described by Bottoni [3] and subsequently by others [4,5,6,7], is used to manage all GRT detachments at the Royal Victorian Eye and Ear Hospital. PFCL remains in the eye for approximately 14 days, before exchange with fluid, air or gas. To investigate whether removal of short-term PFCL tamponade resulted in a lower rate of unexplained vision loss than ROSO in macula-on GRT detachments, we performed a consecutive retrospective review of all macula-on GRT repairs between 19 August 2007 and 12 December 2016. Best-corrected visual acuity (VA) was recorded at initial presentation, and 3 months following PFCL removal. The outcome of the procedure was determined at 3 months. Statistical analysis was performed using a paired student’s t-test assuming equal variance (alpha = 0.05).
A total of 25 eyes in 24 patients (mean age 57 years; range 39–79 years) comprising 4 female patients (16.7%) and 20 male patients (83.3%) were included in the study cohort (Table 1). The mean (range) duration of PFCL tamponade was 14.6 days, (10–28 days) before removal and exchange either with 20 or 25% SF6 gas (n = 13, 52%), air (n = 7, 28%) or balanced salt solution (n = 5, 20%). The mean baseline VA was 76 letters. The mean VA 3 months post-GRT repair was 76 letters, improving to 80 letters after a total of seven patients underwent cataract surgery following a median interval of 6 months (range 4–21 months). This was significantly better than the baseline VA (p < 0.001). The prevalence of visual loss ≥10 letters at 3 months was 4 (16%), which improved to baseline or better in all four following subsequent cataract surgery. Redetachment (macula-on) occurred in two out of 25 patients (8%) following removal of PFCL due to smaller missed breaks. Both were successfully repaired with cryotherapy and gas tamponade.
In keeping with other reports [5,6,7], short-term use of post-operative PFCL in this study was associated with good primary and final anatomical success rates. Notably, in contrast to the reported high rate of vision loss after ROSO in the same patient group i.e. macula-on detachments [1, 8, 9] there were no unexplained visual acuity losses in our series. PFCL may thus mitigate the high incidence of unexplained vision loss after ROSO in those eyes where a good visual outcome is expected. Vitreoretinal surgeons should consider PFCL as an alternative to SiO or gas as a post-operative tamponade agent in macula-on GRT repair.
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Acknowledgements
Additional members of the Vitreoretinal Unit of the Royal Victorian Eye and Ear Hospital who performed surgery on these cases: Drs M F McCombe, D Chiu, R Dawkins, E Roufail, J B Clark and D Fabinyi.
Ethical approval
The study protocol was approved by the Royal Victorian Eye and Ear Human Research Ethics Committee (HREC approval 07/759H) and all procedures were conducted in accordance with the tenets of the Declaration of Helsinki 7th revision.
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Sheridan, A.M., Essex, R.W., Yeoh, J. et al. Is post-operative perfluorocarbon liquid tamponade for macula-on giant retinal tear safer than silicone oil?. Eye 33, 689–691 (2019). https://doi.org/10.1038/s41433-018-0287-9
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DOI: https://doi.org/10.1038/s41433-018-0287-9
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