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OPINION

Going to extremes: determinants of extraordinary response and survival in patients with cancer

Nature Reviews Cancer volume 19, pages 339–348 (2019)Cite this article

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Abstract

Research into factors affecting treatment response or survival in patients with cancer frequently involves cohorts that span the most common range of clinical outcomes, as such patients are most readily available for study. However, attention has turned to highly unusual patients who have exceptionally favourable or atypically poor responses to treatment and/or overall survival, with the expectation that patients at the extremes may provide insights that could ultimately improve the outcome of individuals with more typical disease trajectories. While clinicians can often recount surprising patients whose clinical journey was very unusual, given known clinical characteristics and prognostic indicators, there is a lack of consensus among researchers on how best to define exceptional patients, and little has been proposed for the optimal design of studies to identify factors that dictate unusual outcome. In this Opinion article, we review different approaches to identifying exceptional patients with cancer and possible study designs to investigate extraordinary clinical outcomes. We discuss pitfalls with finding these rare patients, including challenges associated with accrual of patients across different treatment centres and time periods. We describe recent molecular and immunological factors that have been identified as contributing to unusual patient outcome and make recommendations for future studies on these intriguing patients.

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Fig. 1: Classification of patients with an extraordinary treatment response or survival.
Fig. 2: Contrasting patterns of survival in breast and lung cancer.
Fig. 3: Examples of factors influencing exceptionally favourable response to therapy and/or long-term survival.

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References

  1. Bateson, W. The Methods and Scope of Genetics (Cambridge Univ. Press, 1908).

  2. Schwaederle, M. et al. Impact of precision medicine in diverse cancers: a meta-analysis of phase II clinical trials. J. Clin. Oncol. 33, 3817–3825 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Takebe, N., McShane, L. & Conley, B. Biomarkers: exceptional responders-discovering predictive biomarkers. Nat. Rev. Clin. Oncol. 12, 132–134 (2015).

    Article  PubMed  Google Scholar 

  4. Weinberg, R. A. The Biology of Cancer 2nd edn (Garland Science, 2014).

  5. Printz, C. NCI launches exceptional responders initiative: researchers will attempt to identify why some patients respond to treatment so much better than others. Cancer 121, 803–804 (2015).

    Article  PubMed  Google Scholar 

  6. Chang, D. K. et al. Mining the genomes of exceptional responders. Nat. Rev. Cancer 14, 291–292 (2014).

    Article  CAS  PubMed  Google Scholar 

  7. De La Torre, K. et al. Moonshots and metastatic disease: the need for a multi-faceted approach when studying atypical responses. NPJ Breast Cancer 3, 7 (2017).

    Article  CAS  Google Scholar 

  8. Eisenhauer, E. A. et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228–247 (2009).

    Article  CAS  PubMed  Google Scholar 

  9. Seymour, L. et al. iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics. Lancet Oncol. 18, e143–e152 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Rustin, G. J. et al. Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG). Int. J. Gynecol. Cancer 21, 419–423 (2011).

    Article  PubMed  Google Scholar 

  11. Loaiza-Bonilla, A. et al. Dramatic response to dabrafenib and trametinib combination in a BRAF V600E-mutated cholangiocarcinoma: implementation of a molecular tumour board and next-generation sequencing for personalized medicine. Ecancermedicalscience 8, 479 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Colton, B. et al. Exceptional response to systemic therapy in advanced metastatic gastric cancer: a case report. Cureus 8, e457 (2016).

    PubMed  PubMed Central  Google Scholar 

  13. Heyman, J. & Leiter, E. Dramatic response of pulmonary metastasis from prostatic cancer to LH-RH agonist treatment. Mt Sinai J. Med. 56, 108–110 (1989).

    CAS  PubMed  Google Scholar 

  14. Iyer, G. et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 338, 221 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Milowsky, M. I. et al. Phase II study of everolimus in metastatic urothelial cancer. BJU Int. 112, 462–470 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Cantero, D. et al. Molecular study of long-term survivors of glioblastoma by gene-targeted next-generation sequencing. J. Neuropathol. Exp. Neurol. 77, 710–716 (2018).

    Article  PubMed  Google Scholar 

  17. Garsed, D. W. et al. Homologous recombination DNA repair pathway disruption and retinoblastoma protein loss are associated with exceptional survival in high-grade serous ovarian cancer. Clin. Cancer Res. 24, 569–580 (2017).

    Article  CAS  PubMed  Google Scholar 

  18. Jimenez-Sanchez, A. et al. Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient. Cell 170, 927–938 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. University of Michigan School of Public Health. Multidisciplinary Ovarian Cancer Outcomes Group. UMich https://sph.umich.edu/mocog/index.html (2018).

  20. Sud, A., Kinnersley, B. & Houlston, R. S. Genome-wide association studies of cancer: current insights and future perspectives. Nat. Rev. Cancer 17, 692–704 (2017).

    Article  CAS  PubMed  Google Scholar 

  21. Kobel, M. et al. An immunohistochemical algorithm for ovarian carcinoma typing. Int. J. Gynecol. Pathol. 35, 430–441 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. National Cancer Intelligence Network. Overview of Ovarian Cancer in England: Incidence, Mortality and Survival (National Health Service, 2012).

  23. Ma, H., Sun, H. & Sun, X. Survival improvement by decade of patients aged 0–14 years with acute lymphoblastic leukemia: a SEER analysis. Sci. Rep. 4, 4227 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Aletti, G. D. et al. Ovarian cancer surgical resectability: relative impact of disease, patient status, and surgeon. Gynecol. Oncol. 100, 33–37 (2006).

    Article  PubMed  Google Scholar 

  25. Parachoniak, C. A. et al. Exceptional durable response to everolimus in a patient with biphenotypic breast cancer harboring an STK11 variant. Cold Spring Harb. Mol. Case Stud. 3, a000778 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Wagle, N. et al. Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov. 4, 546–553 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  27. Ali, S. M. et al. Exceptional response on addition of everolimus to taxane in urothelial carcinoma bearing an NF2 mutation. Eur. Urol. 67, 1195–1196 (2015).

    Article  CAS  PubMed  Google Scholar 

  28. Wagle, N. et al. Response and acquired resistance to everolimus in anaplastic thyroid cancer. N. Engl. J. Med. 371, 1426–1433 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Moujaber, T. et al. BRAF mutations in low-grade serous ovarian cancer and response to BRAF inhibition. JCO Precis. Oncol. https://doi.org/10.1200/PO.17.00221 (2018).

    Article  PubMed  Google Scholar 

  30. McEvoy, C. R. et al. Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion. J. Clin. Invest. 130, 123089 (2019).

    Google Scholar 

  31. Grisham, R. N. et al. Extreme outlier analysis identifies occult mitogen-activated protein kinase pathway mutations in patients with low-grade serous ovarian cancer. J. Clin. Oncol. 33, 4099–4105 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Mehnert, J. M. et al. Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer. J. Clin. Invest. 126, 2334–2340 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  33. Erson-Omay, E. Z. et al. Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Neuro Oncol. 17, 1356–1364 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Stewart, C. J. et al. Long-term survival of patients with mismatch repair protein-deficient, high-stage ovarian clear cell carcinoma. Histopathology 70, 309–313 (2017).

    Article  PubMed  Google Scholar 

  35. Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 474, 609–615 (2011).

    Article  CAS  Google Scholar 

  36. Patch, A.-M. et al. Whole-genome characterization of chemoresistant ovarian cancer. Nature 521, 489–494 (2015).

    Article  CAS  PubMed  Google Scholar 

  37. Levin, M. K. et al. Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine. Cancer Med. 4, 1289–1293 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Bolton, K. L. et al. Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA 307, 382–390 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Candido-dos-Reis, F. J. et al. Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer. Clin. Cancer Res. 21, 652–657 (2015).

    Article  CAS  PubMed  Google Scholar 

  40. Kotsopoulos, J. et al. Ten-year survival after epithelial ovarian cancer is not associated with BRCA mutation status. Gynecol. Oncol. 140, 42–47 (2016).

    Article  CAS  PubMed  Google Scholar 

  41. Maxwell, K. N. et al. BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers. Nat. Commun. 8, 319 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Wang, Y. et al. The BRCA1-delta11q alternative splice isoform bypasses germline mutations and promotes therapeutic resistance to PARP inhibition and cisplatin. Cancer Res. 76, 2778–2790 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Kondrashova, O. et al. Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma. Nat. Commun. 9, 3970 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Alsop, K. et al. BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group. J. Clin. Oncol. 30, 2654–2663 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917–921 (2005).

    Article  CAS  PubMed  Google Scholar 

  46. Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913–917 (2005).

    Article  CAS  PubMed  Google Scholar 

  47. Necchi, A. et al. Exceptional response to olaparib in BRCA2-altered urothelial carcinoma after PD-L1 inhibitor and chemotherapy failure. Eur. J. Cancer 96, 128–130 (2018).

    Article  CAS  PubMed  Google Scholar 

  48. Lheureux, S. et al. Long-term responders on olaparib maintenance in high-grade serous ovarian cancer: clinical and molecular characterization. Clin. Cancer Res. 23, 4086–4094 (2017).

    Article  CAS  PubMed  Google Scholar 

  49. Fridman, W. H. et al. The immune contexture in cancer prognosis and treatment. Nat. Rev. Clin. Oncol. 14, 717–734 (2017).

    Article  CAS  PubMed  Google Scholar 

  50. Milne, K. et al. Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. PLOS ONE 4, e6412 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Webb, J. R., Milne, K. & Nelson, B. H. PD-1 and CD103 are widely coexpressed on prognostically favorable intraepithelial CD8 T cells in human ovarian cancer. Cancer Immunol. Res. 3, 926–935 (2015).

    Article  CAS  PubMed  Google Scholar 

  52. Djenidi, F. et al. CD8+CD103+tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients. J. Immunol. 194, 3475–3486 (2015).

    Article  CAS  PubMed  Google Scholar 

  53. Wouters, M. C. A. & Nelson, B. H. Prognostic significance of tumor-infiltrating B cells and plasma cells in human cancer. Clin. Cancer Res. 24, 6125–6135 (2018).

    Article  PubMed  Google Scholar 

  54. Blank, C. U. et al. The “cancer immunogram”. Science 352, 658–660 (2016).

    Article  CAS  PubMed  Google Scholar 

  55. Talhouk, A. et al. Molecular subtype not immune response drives outcomes in endometrial carcinoma. Clin. Cancer Res. https://doi.org/10.1158/1078-0432.CCR-18-3241 (2018).

    Article  PubMed  Google Scholar 

  56. Chen, D. S. & Mellman, I. Elements of cancer immunity and the cancer-immune set point. Nature 541, 321–330 (2017).

    Article  CAS  PubMed  Google Scholar 

  57. Lawrence, M. S. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214–218 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Yarchoan, M., Hopkins, A. & Jaffee, E. M. Tumor mutational burden and response rate to PD-1 inhibition. N. Engl. J. Med. 377, 2500–2501 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  59. Le, D. T. et al. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372, 2509–2520 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Overman, M. J. et al. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol. 18, 1182–1191 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Le, D. T. et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 357, 409–413 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Dunn, I. F. et al. Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade. JCO Precis. Oncol. https://doi.org/10.1200/po.18.00190 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  63. Burr, M. L. et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature 549, 101–105 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Shi, Y. Regulatory mechanisms of PD-L1 expression in cancer cells. Cancer Immunol. Immunother. 67, 1481–1489 (2018).

    Article  CAS  PubMed  Google Scholar 

  65. George, J. et al. Genomic amplification of CD274 (PD-L1) in small-cell lung cancer. Clin. Cancer Res. 23, 1220–1226 (2017).

    Article  CAS  PubMed  Google Scholar 

  66. Chong, L. C. et al. Comprehensive characterization of programmed death ligand structural rearrangements in B cell non-Hodgkin lymphomas. Blood 128, 1206–1213 (2016).

    Article  CAS  PubMed  Google Scholar 

  67. Bellone, S. et al. Exceptional response to pembrolizumab in a metastatic, chemotherapy/radiation-resistant ovarian cancer patient harboring a PD-L1-genetic rearrangement. Clin. Cancer Res. 24, 3282–3291 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Goodman, A. M. et al. Prevalence of PDL1 amplification and preliminary response to immune checkpoint blockade in solid tumors. JAMA Oncol. 4, 1237–1244 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  69. Green, M. R. et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B cell lymphoma. Blood 116, 3268–3277 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Amraee, A. et al. Efficacy of nivolumab as checkpoint inhibitor drug on survival rate of patients with relapsed/refractory classical Hodgkin lymphoma: a meta-analysis of prospective clinical study. Clin. Transl Oncol. https://doi.org/10.1007/s12094-018-02032-4 (2019).

    Article  PubMed  Google Scholar 

  71. Miao, D. et al. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science 359, 801–806 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Jelinic, P. et al. Recurrent SMARCA4 mutations in small cell carcinoma of the ovary. Nat. Genet. 46, 424–426 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Jelinic, P. et al. Immune-active microenvironment in small cell carcinoma of the ovary, hypercalcemic type: rationale for immune checkpoint blockade. J. Natl Cancer Inst. 110, 787–790 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  74. Gadducci, A. & Guerrieri, M. E. Immune checkpoint inhibitors in gynecological cancers: update of literature and perspectives of clinical research. Anticancer Res. 37, 5955–5965 (2017).

    CAS  PubMed  Google Scholar 

  75. Wiegand, K. C. et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. N. Engl. J. Med. 363, 1532–1543 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Champiat, S. et al. Hyperprogressive disease is a new pattern of progression in cancer patients treated by anti-PD-1/PD-L1. Clin. Cancer Res. 23, 1920–1928 (2017).

    Article  CAS  PubMed  Google Scholar 

  77. Kato, S. et al. Hyperprogressors after immunotherapy: analysis of genomic alterations associated with accelerated growth rate. Clin. Cancer Res. 23, 4242–4250 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Lo Russo, G. et al. Antibody-Fc/FcR interaction on macrophages as a mechanism for hyperprogressive disease in non-small cell lung cancer subsequent to PD-1/PD-L1 blockade. Clin. Cancer Res. 25, 989–999 (2019).

    Article  PubMed  Google Scholar 

  79. Tran, E. et al. Cancer immunotherapy based on mutation-specific CD4+T cells in a patient with epithelial cancer. Science 344, 641–645 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Zacharakis, N. et al. Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer. Nat. Med. 24, 724–730 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Maude, S. L. et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. N. Engl. J. Med. 378, 439–448 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Park, J. H. et al. Long-term follow-up of CD19 CAR therapy in acute lymphoblastic leukemia. N. Engl. J. Med. 378, 449–459 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Mellman, I., Coukos, G. & Dranoff, G. Cancer immunotherapy comes of age. Nature 480, 480–489 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Sadelain, M., Riviere, I. & Riddell, S. Therapeutic T cell engineering. Nature 545, 423–431 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. June, C. H. & Sadelain, M. Chimeric antigen receptor therapy. N. Engl. J. Med. 379, 64–73 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Fraietta, J. A. et al. Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells. Nature 558, 307–312 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Meyerhardt, J. A. et al. Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J. Natl Cancer Inst. 104, 1702–1711 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Park, S. Y. et al. High-quality diets associate with reduced risk of colorectal cancer: analyses of diet quality indexes in the multiethnic cohort. Gastroenterology 153, 386–394 (2017).

    Article  PubMed  Google Scholar 

  89. Beasley, J. M. et al. Meeting the physical activity guidelines and survival after breast cancer: findings from the after breast cancer pooling project. Breast Cancer Res. Treat. 131, 637–643 (2012).

    Article  PubMed  Google Scholar 

  90. Campbell, P. T. et al. Associations of recreational physical activity and leisure time spent sitting with colorectal cancer survival. J. Clin. Oncol. 31, 876–885 (2013).

    Article  PubMed  Google Scholar 

  91. Cannioto, R. A. et al. Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium. Br. J. Cancer 115, 95–101 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Nagle, C. M. et al. Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium. Br. J. Cancer 113, 817–826 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Nunez, C. et al. Physical activity, obesity and sedentary behaviour and the risks of colon and rectal cancers in the 45 and up study. BMC Public Health 18, 325 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  94. Chan, J. A. et al. Hormone replacement therapy and survival after colorectal cancer diagnosis. J. Clin. Oncol. 24, 5680–5686 (2006).

    Article  CAS  PubMed  Google Scholar 

  95. Symer, M. M. et al. Hormone replacement therapy and colorectal cancer incidence and mortality in the prostate, lung, colorectal, and ovarian cancer screening trial. Clin. Colorectal Cancer 17, e281–e288 (2018).

    Article  PubMed  Google Scholar 

  96. Eeles, R. A. et al. Adjuvant hormone therapy may improve survival in epithelial ovarian cancer: results of the AHT randomized trial. J. Clin. Oncol. 33, 4138–4144 (2015).

    Article  CAS  PubMed  Google Scholar 

  97. Phipps, A. I. et al. Associations between cigarette smoking status and colon cancer prognosis among participants in North Central Cancer Treatment Group phase III trial N0147. J. Clin. Oncol. 31, 2016–2023 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Praestegaard, C. et al. Cigarette smoking is associated with adverse survival among women with ovarian cancer: results from a pooled analysis of 19 studies. Int. J. Cancer 140, 2422–2435 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Jayasekara, H. et al. Associations of alcohol intake, smoking, physical activity and obesity with survival following colorectal cancer diagnosis by stage, anatomic site and tumor molecular subtype. Int. J. Cancer 142, 238–250 (2018).

    Article  CAS  PubMed  Google Scholar 

  100. Molina, Y. et al. Resilience among patients across the cancer continuum: diverse perspectives. Clin. J. Oncol. Nurs. 18, 93–101 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  101. Strauss, B. et al. The influence of resilience on fatigue in cancer patients undergoing radiation therapy (RT). J. Cancer Res. Clin. Oncol. 133, 511–518 (2007).

    Article  PubMed  Google Scholar 

  102. Wenzel, L. B. et al. Resilience, reflection, and residual stress in ovarian cancer survivorship: a gynecologic oncology group study. Psychooncology 11, 142–153 (2002).

    Article  PubMed  Google Scholar 

  103. Pearce, C. L. et al. Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer. Cancer Epidemiol. Biomarkers Prev. 22, 880–890 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  104. Harvard Medical School Department of Biomedical Informatics. Network of Enigmatic Exceptional Responders (NEER) study. People-Powered Medicine https://peoplepoweredmedicine.org/neer (2018).

  105. US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02243592 (2019).

  106. US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02701907 (2018).

  107. US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT03740503 (2018).

  108. US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02321735 (2016).

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Acknowledgements

F.A.M.S. is supported by a Swiss National Foundation Early Postdoc Mobility Fellowship (P2BEP3-172246), Swiss Cancer Research Foundation grant BIL KFS-3942-08-2016 and a Professor Dr Max Cloëtta and Uniscientia Foundation grant. B.H.N., A.dF., C.L.P., M.C.P., D.W.G. and D.D.L.B. are supported by US Army Medical Research and Materiel Command grant W81XWH-16-2-0010. D.D.L.B. is supported by National Health and Medical Research Council of Australia (NHMRC) grants APP1092856 and APP1117044 and by the US National Cancer Institute U54 programme (U54CA209978). The authors acknowledge additional support from Margaret Rose AM and the Rose family, The WeirAnderson Foundation, Border Ovarian Cancer Awareness Group, donors to the Garvan Institute of Medical Research Ovarian Cancer Research Program, the Peter MacCallum Cancer Foundation, Wendy Taylor and Arthur Coombs and family. The Australian Ovarian Cancer Study (AOCS) was supported by the US Army Medical Research and Materiel Command under DAMD17-01-1-0729.

Reviewer information

Nature Reviews Cancer thanks A. Biankin, S. Percy Ivy and the other anonymous reviewer(s) for their contribution to the peer review of this work.

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Authors and Affiliations

  1. Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

    Flurina A. M. Saner, Alan Herschtal, Ahwan Pandey, Jessica A. Beach, Sian Fereday, Dale W. Garsed & David D. L. Bowtell

  2. Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia, Canada

    Brad H. Nelson

  3. Department of Gynaecological Oncology, Westmead Hospital, Westmead, New South Wales, Australia

    Anna deFazio

  4. The University of Sydney, Sydney, New South Wales, Australia

    Anna deFazio

  5. Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia

    Anna deFazio

  6. Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA

    Ellen L. Goode

  7. School of Women’s and Children’s Health, University ofNew South Wales, Sydney, New South Wales, Australia

    Susan J. Ramus

  8. Garvan Institute of Medical Research, Sydney, New South Wales, Australia

    Susan J. Ramus

  9. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA

    Andrew Berchuck

  10. Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Canada

    Stephanie Lheureux

  11. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA

    Celeste Leigh Pearce

  12. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK

    Paul D. Pharoah

  13. Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK

    Paul D. Pharoah

  14. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Malcolm C. Pike

  15. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia

    Dale W. Garsed & David D. L. Bowtell

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Contributions

F.A.M.S., D.W.G. and D.D.L.B. wrote the manuscript and prepared the figures. B.H.N. wrote the section on immunology, and C.L.P. wrote the section on epidemiology. F.A.M.S., A.P. and M.C.P. performed data analyses for the article. A.H., A.dF., E.L.G., S.J.R., J.A.B., S.F., A.B., S.L., P.D.P. and M.C.P. provided a substantial contribution to discussions of the content. D.W.G. and D.D.L.B. contributed equally to supervision of the project. All authors contributed to the review and editing of the article before submission.

Corresponding authors

Correspondence to Dale W. Garsed or David D. L. Bowtell.

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The authors declare no competing interests.

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Related links

Surveillance, Epidemiology and End Results Program: http://www.seer.cancer.gov

Glossary

Complete response

(CR). The disappearance of all target lesions in response to treatment.

Genome-wide association studies

(GWAS). Studies that compare genetic markers across the genome in individuals with and without disease traits.

Hyper-progression

Accelerated disease progression associated with immune checkpoint inhibitor therapy.

Hypomorphic germline alleles

Also called hypomorphic mutations; inherited genetic variants that cause partial (not complete) loss of gene function through reduced expression or function.

Maintenance therapy

Treatment provided following initial therapy to prevent relapse.

Multivariable analyses

Statistical models taking into account the impact of multiple explanatory variables that may influence a single outcome.

Partial response

(PR). A decrease of at least 30% in the sum of the diameters of target lesions in response to treatment.

Polygenic risk

A genetic susceptibility score based on the combination of multiple, often low-penetrance, disease susceptibility alleles.

Synthetic lethality

A phenomenon in cells or organisms whereby two gene or pathway defects occurring in isolation have little or no effect on survival but for which the combination of both leads to death.

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Saner, F.A.M., Herschtal, A., Nelson, B.H. et al. Going to extremes: determinants of extraordinary response and survival in patients with cancer. Nat Rev Cancer 19, 339–348 (2019). https://doi.org/10.1038/s41568-019-0145-5

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