New findings show that disease-specific T cells that target gluten in patients with coeliac disease persist for decades. The data highlight a central role for a highly select and stable population of T cells in disease persistence and support the feasibility of diagnostics and therapies targeting these cells.
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M.H. and J.T.-D. are co-inventors of patents pertaining to the use of gluten peptides in therapeutics, diagnostics, and nontoxic gluten. J.T.-D. holds shares in Nexpep and is on the scientific advisory board of ImmusanT.
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Hardy, M.Y., Tye-Din, J.A. T cells in coeliac disease: a rational target for diagnosis and therapy. Nat Rev Gastroenterol Hepatol 15, 583–584 (2018). https://doi.org/10.1038/s41575-018-0043-4
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DOI: https://doi.org/10.1038/s41575-018-0043-4
