Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HIV RESPONSES

CD4+ T cell signatures in HIV infection

Nature Immunology volume 20, pages 948–950 (2019)Cite this article

Subjects

Analysis of the whole-genome transcriptional activity of HIV-specific CD4+ T cells demonstrates distinct profiles associated with natural control of HIV replication, as well as dysfunctional phenotypes that persist even after effective antiretroviral therapy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Distinct CD4+ T cell signatures in blood in treated and untreated HIV infection.

References

  1. Olson, A.D. et al. PLoS One 9, (2014).

  2. Morou, A. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0418-x (2019).

    Article  CAS  Google Scholar 

  3. Crotty, S. Immunity 41, 529–542 (2014).

    Article  CAS  Google Scholar 

  4. Locci, M. et al. Immunity 39, 758–769 (2013).

    Article  CAS  Google Scholar 

  5. Gautam, R. et al. Nature 533, 105–109 (2016).

    Article  CAS  Google Scholar 

  6. Caskey, M., Klein, F. & Nussenzweig, M. C. Nat. Med. 25, 547–553 (2019).

    Article  CAS  Google Scholar 

  7. Brenchley, J. M. et al. Nat. Med. 12, 1365–1371 (2006).

    Article  CAS  Google Scholar 

  8. Miyauchi, K. et al. Nat. Immunol. 17, 1447–1458 (2016).

    Article  CAS  Google Scholar 

  9. Kahan, S.M. & Zajac, A.J. Sci. Immunol. 2, (2017).

  10. Rao, D. A. et al. Nature 542, 110–114 (2017).

    Article  CAS  Google Scholar 

  11. Banga, R. et al. Nat. Med. 22, 754–761 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

    Celine Gubser, Matthew C Pitman & Sharon R. Lewin

  2. Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia

    Sharon R. Lewin

Authors
  1. Celine Gubser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Matthew C Pitman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sharon R. Lewin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sharon R. Lewin.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gubser, C., Pitman, M.C. & Lewin, S.R. CD4+ T cell signatures in HIV infection. Nat Immunol 20, 948–950 (2019). https://doi.org/10.1038/s41590-019-0447-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0447-5

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing