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Acute left ventricular failure following melphalan and fludarabine conditioning

Bone Marrow Transplantation volume 28, pages 101–103 (2001)Cite this article

Abstract

Cardiotoxicity has rarely been reported as a complication of melphalan or fludarabine administration as single agents. Recently, melphalan and fludarabine have been used in combination as non-myeloablative conditioning chemotherapy prior to allogeneic stem cell transplantation. We have observed the development of severe left ventricular failure in three of 21 patients treated with this combination. Cardiotoxicity in this context has not previously been reported and has implications for the assessment, monitoring and treatment of patients undergoing pre-transplant conditioning with melphalan and fludarabine. Bone Marrow Transplantation (2001) 28, 101–103.

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Authors and Affiliations

  1. Department of Clinical Haematology and Medical Oncology, Bone Marrow Transplant Service, Royal Melbourne Hospital, Melbourne, Australia

    DS Ritchie, AW Roberts, J Szer & AP Grigg

  2. Department of Haematology and Medical Oncology, Peter MacCallum Cancer Institute, Melbourne, Australia

    JF Seymour

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  1. DS Ritchie
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  2. JF Seymour
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  3. AW Roberts
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  4. J Szer
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  5. AP Grigg
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Ritchie, D., Seymour, J., Roberts, A. et al. Acute left ventricular failure following melphalan and fludarabine conditioning. Bone Marrow Transplant 28, 101–103 (2001). https://doi.org/10.1038/sj.bmt.1703098

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