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Liver failure complicating non-alcoholic steatohepatitis following allogeneic bone marrow transplantation for Shwachman–Diamond syndrome

Bone Marrow Transplantation volume 29, pages 931–933 (2002)Cite this article

Abstract

Bone marrow transplantation is potentially curative therapy for the hematologic complications associated with Shwachman–Diamond syndrome (SDS). This syndrome is, however, also associated with significant pancreatic and hepatic dysfunction, which may complicate BMT. We report a case of liver failure due to non-alcoholic steatohepatitis (NASH) following BMT for SDS. This case illustrates the need for assessing liver dysfunction pre-BMT in these patients, in addition to highlighting the potential risk posed by pre-existing steatosis for the development of rapidly progressive hepatic failure following transplantation.

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Authors and Affiliations

  1. Department of Clinical Haematology and Medical Oncology, Bone Marrow Transplant Service, Royal Melbourne Hospital, Melbourne, Australia

    DS Ritchie & AP Grigg

  2. Department of Gastroenterology, Austin-Repatriation Hospital, Melbourne, Australia

    PW Angus

  3. Department of Anatomical Pathology, Royal Melbourne Hospital, Melbourne, Australia

    PS Bhathal

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  1. DS Ritchie
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  2. PW Angus
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  3. PS Bhathal
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  4. AP Grigg
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Ritchie, D., Angus, P., Bhathal, P. et al. Liver failure complicating non-alcoholic steatohepatitis following allogeneic bone marrow transplantation for Shwachman–Diamond syndrome. Bone Marrow Transplant 29, 931–933 (2002). https://doi.org/10.1038/sj.bmt.1703549

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  • DOI: https://doi.org/10.1038/sj.bmt.1703549

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