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Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

Oncogene volume 18, pages 5268–5277 (1999)Cite this article

Abstract

The pathways to lymphoid neoplasia have been explored in a number of transgenic models. Because B lymphoid malignancies often involve translocation of an oncogene (e.g. myc, bcl-2, cyclin D1) to an immunoglobulin locus, resulting in its deregulated expression, the consequences of oncogene overexpression in lymphocytes can be evaluated with transgenes driven by an immunoglobulin regulatory element, such as an enhancer from the IgH locus. Mice bearing such transgenes have provided insight into the preneoplastic state, including alterations in the control of cellular proliferation, differentiation or apoptosis. They have also allowed studies on oncogene cooperation in vivo and the modulating effect of genetic background. Briefly reviewed here are the models studied in the authors’ laboratories. Mice bearing myc and bcl-2 transgenes have received most attention but others studied include abl, ras, cyclin D1 and bmi-1 oncogenes. Also discussed is a new transgenic vector that should facilitate transgenic approaches to non-lymphoid leukemias. The vector bears elements from the promoter region of the vav gene, which is expressed almost exclusively in hematopoietic cells. It has proven capable of driving transgene expression throughout the hematopoietic compartment, including progenitor cells and their precursors. This novel vector should aid studies on many aspects of hematopoiesis, including the modeling of leukemogenesis.

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Acknowledgements

We are grateful for the contributions of the many colleagues who have worked on these transgenic models. In particular, Sue Bath made many of the transgenic mice and Andrew Elefanty launched the vav studies, to which Donald Metcalf also contributed importantly. This work was supported by the National Health and Medical Research Council (Reg. Key 973002), the US National Cancer Institute (CA43540 and CA80188), the Dr Josef Steiner Cancer Research Foundation and the Anti-Cancer Council of Victoria. A Strasser is a Scholar of the Leukemia Society of America.

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  1. The Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, Melbourne, Victoria, 3050, Australia

    J M Adams, A W Harris, A Strasser, S Ogilvy & S Cory

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Adams, J., Harris, A., Strasser, A. et al. Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector. Oncogene 18, 5268–5277 (1999). https://doi.org/10.1038/sj.onc.1202997

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