Issue 1147, 1971
From the journal:

Analyst

A potentiometric procedure for the assay of isonicotinic acid hydrazide (isoniazid)

P. V. Krishna Rao  and  G. Bala Bhaskara Rao  

Abstract

A potentiometric procedure for the assay of isonicotinic acid hydrazide (isoniazid) with vanadium(V) at room temperature is described. The reduction of vanadium(V) to vanadium(IV) by isoniazid in an acidic medium is catalysed by osmium tetroxide, and the application of this method to the assay of isoniazid in pharmaceutical preparations is considered. Oxalic acid interferes in the determination, although commonly used excipients such as starch, dextrin, sucrose, glucose, lactose and gum acacia do not interfere.

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Article information

DOI
https://doi.org/10.1039/AN9719600712
Article type
Paper

Analyst, 1971,96, 712-715

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A potentiometric procedure for the assay of isonicotinic acid hydrazide (isoniazid)

P. V. K. Rao and G. B. B. Rao, Analyst, 1971, 96, 712 DOI: 10.1039/AN9719600712

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