Issue 9, 1995
From the journal:

Analyst

Determination of furazolidone in porcine tissue using thermospray liquid chromatography–mass spectrometry and a study of the pharmacokinetics and stability of its residues

Robert J. McCracken,   W. John Blanchflower,   Chris Rowan,   Maurice A. McCoy  and  D. Glenn Kennedy  

Abstract

A method is presented for the detection of the nitrofuran, furazolidone, in porcine tissue. Following methanol–buffer extraction of the tissue, liquid partitioning, and solid-phase clean-up, samples are analysed by using thermospray LC–MS monitoring the positive ion m/z 243 with filament-assisted ionization. The LOD is 1 µg kg–1. The assay is used to investigate the depletion of furazolidone from tissue and sample stability post mortem. It is necessary to snap-freeze samples by immersion in liquid nitrogen immediately upon collection in order to improve the stability of residues in tissue.

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Article information

DOI
https://doi.org/10.1039/AN9952002347
Article type
Paper

Analyst, 1995,120, 2347-2351

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Determination of furazolidone in porcine tissue using thermospray liquid chromatography–mass spectrometry and a study of the pharmacokinetics and stability of its residues

R. J. McCracken, W. J. Blanchflower, C. Rowan, M. A. McCoy and D. G. Kennedy, Analyst, 1995, 120, 2347 DOI: 10.1039/AN9952002347

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