Issue 5, 2002
From the journal:

Physical Chemistry Chemical Physics

Pairing of the nucleobases guanine and cytosine in the gas phase studied by IR–UV double-resonance spectroscopy and ab initio calculations

E. Nir,a   Ch. Janzen,b   P. Imhof,b   K. Kleinermannsb  and  M. S. de Vriesc  

a Department of Chemistry, The Hebrew University, Jerusalem 91904, Israel

b Institut für Physikalische Chemie und Elektrochemie I, Heinrich Heine Universität Duesseldorf, Düsseldorf, Germany

c Department of Chemistry and Biochemistry, University of California, Santa Barbara, USA

Abstract

We present R2PI, IR–UV and UV–UV double resonance measurements of the guanine–cytosine (G–C) dimer formed in a supersonic jet. We show that there is only one isomer of G–C in the investigated wavelength range from 33200 to 34100 cm−1. We assigned the observed G–C isomer to a specific structure, based on comparisons of the IR spectra of the G and C monomers with the G–C dimer in the range of the OH and NH stretching vibrations and ab initio-calculated vibrational frequencies and dimer stabilities. The cluster exhibits an HNH⋯O/NH⋯N/C[double bond, length half m-dash]O⋯HNH bonding similar to the Watson–Crick G–C base pair bonding but with C as the enol tautomer. We did not observe any keto–keto or enol–enol G–C dimers in the investigated wavelength region.

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Article information

DOI
https://doi.org/10.1039/B107429F
Article type
Paper
Submitted
16 Aug 2001
Accepted
08 Nov 2001
First published
29 Jan 2002

Phys. Chem. Chem. Phys., 2002,4, 732-739

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Pairing of the nucleobases guanine and cytosine in the gas phase studied by IR–UV double-resonance spectroscopy and ab initio calculations

E. Nir, Ch. Janzen, P. Imhof, K. Kleinermanns and M. S. de Vries, Phys. Chem. Chem. Phys., 2002, 4, 732 DOI: 10.1039/B107429F

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