Issue 4, 2002
From the journal:

Chemical Communications

Squalene–hopene cyclase: catalytic mechanism and substrate recognition

Tsutomu Hoshino*a  and  Tsutomu Satoa  

* Corresponding authors

a Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, Ikarashi, Niigata, Japan
E-mail: hoshitsu @agr.niigata-u.ac.jp

Abstract

Rapid progress on the catalytic mechanism and substrate recognition by squalene–hopene cyclase, which has occurred only in the last several years, is reported. A series of site-directed mutation experiments and some squalene analogues have provided deep insight into the polycyclization mechanism and catalytic sites in conjunction with the information from X-ray crystal data.

Graphical abstract: Squalene–hopene cyclase: catalytic mechanism and substrate recognition

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Article information

DOI
https://doi.org/10.1039/B108995C
Article type
Feature Article
Submitted
03 Oct 2001
Accepted
09 Nov 2001
First published
17 Jan 2002

Chem. Commun., 2002, 291-301

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Squalene–hopene cyclase: catalytic mechanism and substrate recognition

T. Hoshino and T. Sato, Chem. Commun., 2002, 291 DOI: 10.1039/B108995C

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