Issue 1, 2003
From the journal:

Green Chemistry

A novel and simple method for the silylation of alcohols in DMSO–hexane without a catalyst

Tsutomu Watahiki,a   Masaya Matsuzakia  and  Takeshi Oriyama*a  

* Corresponding authors

a Department of Environmental Sciences, Faculty of Science, Ibaraki University, 2-1-1 Bunkyo, Mito, Japan
E-mail: tor@mx.ibaraki.ac.jp

Abstract

Reaction of alcohols with tert-butyldimethylsilyl chloride in DMSO–hexane provides the corresponding tert-butyldimethylsilyl ethers in high yields under mild reaction conditions. This convenient reaction proceeds very smoothly at room temperature without a catalyst. Additionally, alcohols having an allylic alcohol, cyclopropane, and tetrahydrofuran moiety underwent chemoselective silylation to give the TBS ethers in good yields with no undesired reactions.

Graphical abstract: A novel and simple method for the silylation of alcohols in DMSO–hexane without a catalyst

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Article information

DOI
https://doi.org/10.1039/B209506H
Article type
Paper
Submitted
27 Sep 2002
First published
16 Jan 2003

Green Chem., 2003,5, 82-84

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A novel and simple method for the silylation of alcohols in DMSO–hexane without a catalyst

T. Watahiki, M. Matsuzaki and T. Oriyama, Green Chem., 2003, 5, 82 DOI: 10.1039/B209506H

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