Issue 10, 2004
From the journal:

Physical Chemistry Chemical Physics

Conformers of the peptides glycine-tryptophan, tryptophan-glycine and tryptophan-glycine-glycine as revealed by double resonance laser spectroscopy

I. Hüniga  and  K. Kleinermanns*a  

* Corresponding authors

a Institut für Physikalische Chemie und Elektrochemie 1, Heinrich-Heine-Universität-Düsseldorf, Düsseldorf, Germany
E-mail: kleinermanns@uni-duesseldorf.de

Abstract

The peptides Trp-Gly, Gly-Trp and Trp-Gly-Gly were investigated by UV–UV and IR–UV hole burning spectroscopy. Solid samples of the three peptides were vaporised into an argon jet by laser desorption. The IR–UV spectra of different conformers of the peptides were assigned by comparison with the IR–UV spectra of tryptophan [Snoek et al., Phys. Chem. Chem. Phys., 2001, 3, 1819], the free peptide bond in N-acetyl tryptophan methyl amide [Dian et al., J. Chem. Phys., 2002, 117, 10 688] and ab initio calculations performed at the DFT B3LYP 6-31G(d,p) level. Apart from an NH⋯NH2 interaction, the peptide backbone of one conformer of each dipeptide is unfolded. The second conformer of Gly-Trp shows a COOH⋯O[double bond, length as m-dash]C hydrogen bond and the second conformer of Trp-Gly-Gly a hydrogen bond between the peptide backbone and the NH group of the indole ring.

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Article information

DOI
https://doi.org/10.1039/B316295H
Article type
Paper
Submitted
15 Dec 2003
Accepted
30 Jan 2004
First published
27 Feb 2004

Phys. Chem. Chem. Phys., 2004,6, 2650-2658

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Conformers of the peptides glycine-tryptophan, tryptophan-glycine and tryptophan-glycine-glycine as revealed by double resonance laser spectroscopy

I. Hünig and K. Kleinermanns, Phys. Chem. Chem. Phys., 2004, 6, 2650 DOI: 10.1039/B316295H

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