Issue 9, 2004

Towards nuclear magnetic resonance μ-spectroscopy and μ-imaging

Abstract

The first successful experiments demonstrating Nuclear Magnetic Resonance (NMR) were a spin-off from the development of electromagnetic technology and its introduction into civilian life in the late forties. It was soon discovered that NMR spectra held chemically relevant information making it useful as an analytical tool. By introducing a new way of detection, moving away from continuous wave spectroscopy, Fourier Transform NMR helped to overcome sensitivity problems and subsequently opened the way for multi-dimensional spectroscopy. As a result NMR has developed into one of the most powerful analysis techniques with widespread applications. Still sensitivity is a limiting factor in the applicability of NMR. Therefore we witness a renaissance of technique development in magnetic resonance striving to improve its receptiveness. This tutorial review introduces the efforts currently made in miniaturizing inductive detection by designing optimal radio-frequency microcoils. A second approach is to introduce a new way of detecting magnetic resonance signals by means of very sensitive micromechanical force detectors. This shows that the detection limits in terms of absolute sensitivity or imaging resolution are still open to significant improvements.

Article information

Article type
Tutorial Review
Submitted
24 Mar 2004
Accepted
14 Jun 2004
First published
05 Aug 2004

Analyst, 2004,129, 793-803

Towards nuclear magnetic resonance μ-spectroscopy and μ-imaging

P. J. M. V. Bentum, J. W. G. Janssen and A. P. M. Kentgens, Analyst, 2004, 129, 793 DOI: 10.1039/B404497P

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