Issue 9, 2006
From the journal:

Organic & Biomolecular Chemistry

Development of drug intermediates by using direct organocatalytic multi-component reactions

Dhevalapally B. Ramachary,*a   M. Kishora  and  G. Babul Reddya  

* Corresponding authors

a School of Chemistry, University of Hyderabad, Hyderabad, India
E-mail: ramsc@uohyd.ernet.in
Fax: +91-40-23012460

Abstract

Novel, economic and environmentally friendly one-pot three-component Knoevenagel/hydrogenation (K/H) and four-component Knoevenagel/hydrogenation/alkylation (K/H/A) reactions of ketones, CH-acids, dihydropyridines and alkyl halides using proline and proline/metal carbonate catalysis, respectively, have been developed. Many of the products of these K/H and K/H/A reactions have direct applications in pharmaceutical chemistry.

Graphical abstract: Development of drug intermediates by using direct organocatalytic multi-component reactions

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Article information

DOI
https://doi.org/10.1039/B602696F
Article type
Communication
Submitted
22 Feb 2006
Accepted
14 Mar 2006
First published
23 Mar 2006

Org. Biomol. Chem., 2006,4, 1641-1646

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Development of drug intermediates by using direct organocatalytic multi-component reactions

D. B. Ramachary, M. Kishor and G. B. Reddy, Org. Biomol. Chem., 2006, 4, 1641 DOI: 10.1039/B602696F

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