Issue 8, 2009
From the journal:

Chemical Society Reviews

Nanopore analytics: sensing of single molecules

Stefan Howorkaa  and  Zuzanna Siwyb  

a Department of Chemistry, Institute of Structural Molecular Biology, University College London, London, UK
E-mail: s.howorka@ucl.ac.uk

b School of Physical Sciences, University of California at Irvine, 210G Rowland Hall, Mail Code: 4575, Irvine, USA
E-mail: zsiwy@uci.edu

Abstract

In nanopore analytics, individual molecules pass through a single nanopore giving rise to detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore analytics has gained popularity and can be conducted with natural protein as well as man-made polymeric and inorganic pores. The spectrum of detectable analytes ranges from nucleic acids, peptides, proteins, and biomolecular complexes to organic polymers and small molecules. Apart from being an analytical tool, nanopores have developed into a general platform technology to investigate the biophysics, physicochemistry, and chemistry of individual molecules (critical review, 310 references).

Graphical abstract: Nanopore analytics: sensing of single molecules

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Article information

DOI
https://doi.org/10.1039/B813796J
Article type
Critical Review
Submitted
17 Feb 2009
First published
15 Jun 2009

Chem. Soc. Rev., 2009,38, 2360-2384

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Nanopore analytics: sensing of single molecules

S. Howorka and Z. Siwy, Chem. Soc. Rev., 2009, 38, 2360 DOI: 10.1039/B813796J

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