Issue 4, 2011
From the journal:

Analytical Methods

Nanomolar detection of guanine based on a novel cobalt oxide nanostructure-modified glassy carbon electrode

Rahman Hallaja  and  Abdollah Salimi*ab  

* Corresponding authors

a Department of Chemistry, University of Kurdistan, P.O.Box 416, Sanandaj, Iran
E-mail: absalimi@uok.ac.ir, absalimi@yahoo.com
Fax: +98-871-6624001
Tel: +98-871-6660075

b Research Center for Nanotechnology, University of Kurdistan, P.O.Box 416, Sanandaj, Iran

Abstract

Cyclic voltammetry was used for modification of a glassy carbon electrode with uniform worm-like cobalt oxide nanostructures (CoOx-NSt) with diameter 20–30 nm and length 100–300 nm. The electrochemical properties and morphological characterization of the modified electrode were characterized by cyclic voltammetry, SEM and AFM. The modified electrode showed a well-defined redox couple and excellent electrocatalytic activity toward guanine oxidation in a wide pH range, 5–13. The modified electrode was used as a novel amperometric sensor for guanine determination in the nanomolar–micromolar concentration range. The detection limit, sensitivity and linear calibration range of the sensor are 3 nM, 22.3 nA nM−1 cm−2 and 40 nM–10 μM, using amperommetry. Simplicity of fabrication, excellent electrocatalytic ability, high stability and fast response time are other advantages of the designed sensor. Furthermore, antifouling properties of novel cobalt oxide nanostructures toward guanine and its oxidation products improved reproducibility and repeatability of the proposed sensor.

Graphical abstract: Nanomolar detection of guanine based on a novel cobalt oxide nanostructure-modified glassy carbon electrode

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Article information

DOI
https://doi.org/10.1039/C0AY00675K
Article type
Paper
Submitted
06 Nov 2010
Accepted
03 Feb 2011
First published
17 Feb 2011

Anal. Methods, 2011,3, 911-918

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Nanomolar detection of guanine based on a novel cobalt oxide nanostructure-modified glassy carbon electrode

R. Hallaj and A. Salimi, Anal. Methods, 2011, 3, 911 DOI: 10.1039/C0AY00675K

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