Issue 23, 2010

3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis

Abstract

The first synthesis of 3-methoxalylchromone was described. The reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO2Me substituent located at the α-position of the pyridine core.

Graphical abstract: 3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2010
Accepted
13 Sep 2010
First published
11 Oct 2010

Org. Biomol. Chem., 2010,8, 5280-5284

3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis

S. Mkrtchyan, V. O. Iaroshenko, S. Dudkin, A. Gevorgyan, M. Vilches-Herrera, G. Ghazaryan, D. M. Volochnyuk, D. Ostrovskyi, Z. Ahmed, A. Villinger, V. Ya. Sosnovskikh and P. Langer, Org. Biomol. Chem., 2010, 8, 5280 DOI: 10.1039/C0OB00379D

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