Issue 13, 2011
From the journal:

Analyst

Urine analysis in microfluidic devices

Chun-Che Lin,ab   Chin-Chung Tseng,c   Tsung-Kai Chuang,d   Der-Seang Leee  and  Gwo-Bin Lee*f  

* Corresponding authors

a Department of Engineering Science, National Cheng Kung University, Tainan, Taiwan

b Kaohsiung Medical Device Special Zone, Metal Industries Research & Development Centre, Kaohsiung, Taiwan

c Division of Nephrology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

d Department of Styling and Cosmetology, Tainan University of Technology, Tainan, Taiwan

e Department of Pharmacy, Chia Nan University of Pharmacy & Science, Tainan, Taiwan

f Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan
E-mail: gwobin@pme.nthu.edu.tw
Fax: +886-3-5722840
Tel: +886-3-5715131 Ext. 33765

Abstract

Microfluidics has attracted considerable attention since its early development in the 1980s and has experienced rapid growth in the past three decades due to advantages associated with miniaturization, integration and automation. Urine analysis is a common, fast and inexpensive clinical diagnostic tool in health care. In this article, we will be reviewing recent works starting from 2005 to the present for urine analysis using microfluidic devices or systems and to provide in-depth commentary about these techniques. Moreover, commercial strips that are often treated as chips and their readers for urine analysis will also be briefly discussed. We start with an introduction to the physiological significance of various components or measurement standards in urine analysis, followed by a brief introduction to enabling microfluidic technologies. Then, microfluidic devices or systems for sample pretreatments and for sensing urinary macromolecules, micromolecules, as well as multiplexed analysis are reviewed, in this sequence. Moreover, a microfluidic chip for urinary proteome profiling is also discussed, followed by a section discussing commercial products. Finally, the authors' perspectives on microfluidic-based urine analysis are provided. These advancements in microfluidic techniques for urine analysis may improve current routine clinical practices, particularly for point-of-care (POC) applications.

Graphical abstract: Urine analysis in microfluidic devices

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Article information

DOI
https://doi.org/10.1039/C1AN15029D
Article type
Critical Review
Submitted
11 Jan 2011
Accepted
15 May 2011
First published
27 May 2011

Analyst, 2011,136, 2669-2688

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Urine analysis in microfluidic devices

C. Lin, C. Tseng, T. Chuang, D. Lee and G. Lee, Analyst, 2011, 136, 2669 DOI: 10.1039/C1AN15029D

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