Issue 10, 2011
From the journal:

Chemical Society Reviews

Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles†

Pazhamalai Anbarasan,a   Thomas Schareinaa  and  Matthias Beller*a  

* Corresponding authors

a Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29A, 18059 Rostock, Germany
E-mail: matthias.beller@catalysis.de
Web: http://www.catalysis.de/
Fax: +49 381-1281-5000
Tel: +49 (0)381-12810

Abstract

The palladium-catalyzed cyanation of Ar–X (X = I, Br, Cl, OTf, and H) allows for an efficient access towards benzonitriles. After its discovery in 1973 and following significant improvements in recent decades, this methodology has become nowadays the most popular for preparation of substituted aromatic nitriles. In this critical review, we summarize the important developments in this area from 2000 until 2010 (151 references).

Graphical abstract: Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles

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Article information

DOI
https://doi.org/10.1039/C1CS15004A
Article type
Critical Review
Submitted
07 Jan 2011
First published
28 Apr 2011

Chem. Soc. Rev., 2011,40, 5049-5067

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Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles

P. Anbarasan, T. Schareina and M. Beller, Chem. Soc. Rev., 2011, 40, 5049 DOI: 10.1039/C1CS15004A

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