Issue 5, 2012

Chiral nickel(ii) complexes in the preparation of 11C- and 18F-labelled enantiomerically pure α-amino acids

Abstract

Positron emission tomography (PET) utilises positron emitting radiopharmaceuticals in the study of metabolic and physiological processes. FDG-PET is a useful technique for tumour detection; however FDG has disadvantages. The incorporation of labelled amino acids into brain tumours and into some other organs with high physiological consumption of glucose is a superior diagnostic method due to its much higher selectivity compared to FDG. A Ni(II) complex with a Schiff base of BPB and glycine was one of the first glycine synthons used for asymmetric synthesis of carbon-11 and fluorine-18 labelled α-amino acids. A similar complex was employed for routine preparation of [18F]FET. Physico-chemical investigations allowed us to design modified complexes with much stronger stereodiscriminative power including stereospecific ones. Chiral nickel complexes are also used for the preparation of tailored amino acids for the incorporation into peptides followed by labelling the peptides with fluorine-18 labelled "click" reagents. This review covers PET applications of Ni(II) complexes of Schiff base of BPB and α-amino acids from 1989 to date.

Graphical abstract: Chiral nickel(ii) complexes in the preparation of 11C- and 18F-labelled enantiomerically pure α-amino acids

Article information

Article type
Perspective
Submitted
05 Sep 2011
Accepted
25 Oct 2011
First published
08 Dec 2011

Dalton Trans., 2012,41, 1430-1440

Chiral nickel(II) complexes in the preparation of 11C- and 18F-labelled enantiomerically pure α-amino acids

A. Popkov and B. De Spiegeleer, Dalton Trans., 2012, 41, 1430 DOI: 10.1039/C1DT11675D

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