Issue 48, 2012
From the journal:

Organic & Biomolecular Chemistry

Potassium iodide catalyzed simultaneous C3-formylation and N-aminomethylation of indoles with 4-substituted-N,N-dimethylanilines†

Lan-Tao Li,a   Hong-Ying Li,a   Li-Juan Xing,a   Li-Juan Wen,a   Peng Wang*a  and  Bin Wang*a  

* Corresponding authors

a State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, 94 Weijin Road, Tianjin 300071, China
E-mail: wangbin@nankai.edu.cn, pwang@nankai.edu.cn
Fax: (+86)-22-23507760
Tel: (+86)-22-23506290

Abstract

A one-pot dual functionalization of indoles has been developed. The simultaneous C3-formylation and N-aminomethylation of indoles can be achieved using readily available potassium iodide as a catalyst and tert-butyl peroxybenzoate as a co-oxidant.

Graphical abstract: Potassium iodide catalyzed simultaneous C3-formylation and N-aminomethylation of indoles with 4-substituted-N,N-dimethylanilines

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Article information

DOI
https://doi.org/10.1039/C2OB26636A
Article type
Communication
Submitted
17 Aug 2012
Accepted
01 Nov 2012
First published
01 Nov 2012

Org. Biomol. Chem., 2012,10, 9519-9522

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Potassium iodide catalyzed simultaneous C3-formylation and N-aminomethylation of indoles with 4-substituted-N,N-dimethylanilines

L. Li, H. Li, L. Xing, L. Wen, P. Wang and B. Wang, Org. Biomol. Chem., 2012, 10, 9519 DOI: 10.1039/C2OB26636A

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