SCHEDULED MAINTENANCE
Isomeric Mannich bases derived from unsymmetrical ketones can be synthesised regioselectively simply by selecting the reaction conditions; reaction of dimethyl(methylene)ammonium trifluoroacetate in trifluoroacetic acid yields the more substituted aminoketone while reaction of di-isopropyl(methylene)ammonium perchlorate in acetonitrile leads to the less substituted aminoketone.
Y. Jasor, M. Luche, M. Gaudry and A. Marquet, J. Chem. Soc., Chem. Commun., 1974, 253b DOI: 10.1039/C3974000253B
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