Issue 13, 1977
From the journal:

Journal of the Chemical Society, Chemical Communications

Effective homogeneous hydrogenation of α-keto esters catalysed by neutral rhodium(I) complexes with phosphine ligands and application to the asymmetric synthesis of lactates

Iwao Ojima,   Tetsuo Kogure  and  Kazuo Achiwa  

Abstract

The hydrogenation of α-keto esters was found to be catalysed effectively by neutral rhodium(I) complexes with phosphine ligands, and the asymmetric hydrogenation of pyruvates was carried out using the rhodium(I) complexes with chiral diphosphines 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (diop), and (2S,4S)-N-t-butoxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine (bppm), in dry benzene or tetrahydrofuran to give optically active lactates (36–76% enantiomeric excess) in nearly quantitative yields.

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Article information

DOI
https://doi.org/10.1039/C39770000428
Article type
Paper

J. Chem. Soc., Chem. Commun., 1977, 428-430

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Effective homogeneous hydrogenation of α-keto esters catalysed by neutral rhodium(I) complexes with phosphine ligands and application to the asymmetric synthesis of lactates

I. Ojima, T. Kogure and K. Achiwa, J. Chem. Soc., Chem. Commun., 1977, 428 DOI: 10.1039/C39770000428

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