The synthesis is reported of the bis-daunomycin derivatives (5a–g) which have been shown conclusively to act as bis-intercalating agents of DNA and also to exhibit slow DNA-dissociation kinetics.
R. T. C. Brownlee, P. Cacioli, C. J. Chandler, D. R. Phillips, P. A. Scourides and J. A. Reiss, J. Chem. Soc., Chem. Commun., 1986, 659 DOI: 10.1039/C39860000659
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