Issue 2, 1992

N-substituted pyrrolidin-3-ones as heterocyclic building blocks. Enantioselective synthesis of 8-epi- and 1,8,8a-triepi-castanospermine

Abstract

Regioselective aldol reaction of dianion 1 with aldehyde 5 provides the basis of a new approach to the construction of polyhydroxy indolizidines and the application of this methodology to the synthesis of 8-epicastanospermine 11 and 1,8,8a-triepicastanospermine 12 is described.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1992, 166-168

N-substituted pyrrolidin-3-ones as heterocyclic building blocks. Enantioselective synthesis of 8-epi- and 1,8,8a-triepi-castanospermine

T. Gallagher, M. Giles, R. S. Subramanian and M. S. Hadley, J. Chem. Soc., Chem. Commun., 1992, 166 DOI: 10.1039/C39920000166

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