Peptide nucleic acid (PNA) monomer building blocks for the introduction of G and A are prepared and used to synthesise H-T4XT5-Lys-NH2(X = G or A), which are shown by Tm measurements to recognize their complementary DNA sequences in both the parallel (N-terminal PNA/5′-DNA) and the anti-parallel mode; the stoichiometry in each case is (PNA)2/DNA.
M. Egholm, C. Behrens, L. Christensen, R. H. Berg, P. E. Nielsen and O. Buchardt, J. Chem. Soc., Chem. Commun., 1993, 800 DOI: 10.1039/C39930000800
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