Issue 6, 1994

Intermolecular displacement of S-bound L-methionine on platinum(II) by guanosine 5′-monophosphate: implications for the mechanism of action of anticancer drugs

Abstract

NMR investigations of the kinetics and thermodynamics of the competitive binding of L-methionine (Met), L-histidine (His), and 5′-monophosphates of guanosine (5′-GMP), adenosine (5′-AMP), thymidine (5′-TMP) and cytidine (5′-CMP) to [Pt(dien)Cl]+(dien = 1,5-diamino-3-azapentane) in aqueous solution show that 5′-GMP selectively displaces S-bound Met, a finding which has implications for DNA platination by anticancer drugs in vivo.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1994, 721-722

Intermolecular displacement of S-bound L-methionine on platinum(II) by guanosine 5′-monophosphate: implications for the mechanism of action of anticancer drugs

K. J. Barnham, M. I. Djuran, P. del Socorro Murdoch and P. J. Sadler, J. Chem. Soc., Chem. Commun., 1994, 721 DOI: 10.1039/C39940000721

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