Issue 1, 2014
From the journal:

Natural Product Reports

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

Hemant Kumar,a   In-Su Kim,a   Sandeep Vasant More,a   Byung-Wook Kima  and  Dong-Kug Choi*a  

* Corresponding authors

a Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Korea
E-mail: choidk@kku.ac.kr
Fax: +82-43-840-3872
Tel: +82-43-840-3610

Abstract

Covering: 2000 to 2013

Oxidative stress is the central component of chronic diseases. The nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway is vital in the up-regulation of cytoprotective genes and enzymes in response to oxidative stress and treatment with certain dietary phytochemicals. Herein, we classify bioactive compounds derived from natural products that are Nrf2/ARE pathway activators and recapitulate the molecular mechanisms for inducing Nrf2 to provide favorable effects in experimental models of chronic diseases. Moreover, pharmacological inhibition of Nrf2 signalling has emerged as promising strategy against multi-drug resistance thereby improving the treatment efficacy. We have also enlisted natural product-derived inhibitors of Nrf2/ARE pathway.

Graphical abstract: Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

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Article information

DOI
https://doi.org/10.1039/C3NP70065H
Article type
Review Article
Submitted
16 Jul 2013
First published
29 Nov 2013

Nat. Prod. Rep., 2014,31, 109-139

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Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

H. Kumar, I. Kim, S. V. More, B. Kim and D. Choi, Nat. Prod. Rep., 2014, 31, 109 DOI: 10.1039/C3NP70065H

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