Issue 97, 2015
From the journal:

Chemical Communications

The copper binding properties of metformin – QCM-D, XPS and nanobead agglomeration†

Xueling Quan,‡*a   Rokon Uddin,‡a   Arto Heiskanen,a   Mattias Parmvi,a   Katharina Nilson,b   Marco Donolato,a   Mikkel F. Hansen,a   Graham Renac  and  Anja Boisen*a  

* Corresponding authors

a Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
E-mail: Anja.Boisen@nanotech.dtu.dk, Xueling.Quan@nanotech.dtu.dk
Tel: +45 45255727

b DTU DANCHIP, Technical University of Denmark, Building 347, Kgs. Lyngby DK-2800, Denmark

c Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK

Abstract

Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and L-cysteine–copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

Graphical abstract: The copper binding properties of metformin – QCM-D, XPS and nanobead agglomeration

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Article information

DOI
https://doi.org/10.1039/C5CC04321B
Article type
Communication
Submitted
26 May 2015
Accepted
07 Sep 2015
First published
07 Sep 2015

Chem. Commun., 2015,51, 17313-17316

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The copper binding properties of metformin – QCM-D, XPS and nanobead agglomeration

X. Quan, R. Uddin, A. Heiskanen, M. Parmvi, K. Nilson, M. Donolato, M. F. Hansen, G. Rena and A. Boisen, Chem. Commun., 2015, 51, 17313 DOI: 10.1039/C5CC04321B

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