Issue 39, 2016
From the journal:

Chemical Communications

A direct access to isoxazoles from ynones using trimethylsilyl azide as amino surrogate under metal/catalyst free conditions†

Gadi Ranjith Kumar,‡ab   Yalla Kiran Kumar‡a  and  Maddi Sridhar Reddy*ab  

* Corresponding authors

a Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India
E-mail: msreddy@cdri.res.in

b Academy of Scientific and Innovative Research, New Delhi 110001, India

Abstract

A general method for isoxazoles from readily available ynones using trimethylsilyl azide as an amino surrogate, likely via an unprecedented hydroazidation of the alkyne and denitrogenative cyclization, is demonstrated. The method neither required any catalyst nor demanded unusual conditions to afford the products with outstanding functional group compatibility.

Graphical abstract: A direct access to isoxazoles from ynones using trimethylsilyl azide as amino surrogate under metal/catalyst free conditions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC02047J
Article type
Communication
Submitted
08 Mar 2016
Accepted
13 Apr 2016
First published
13 Apr 2016

Chem. Commun., 2016,52, 6589-6592

Permissions

Request permissions

A direct access to isoxazoles from ynones using trimethylsilyl azide as amino surrogate under metal/catalyst free conditions

G. R. Kumar, Y. K. Kumar and M. S. Reddy, Chem. Commun., 2016, 52, 6589 DOI: 10.1039/C6CC02047J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements