Issue 20, 2020
From the journal:

Chemical Communications

Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells†

Shohei Uchinomiya,a   Naoya Matsunaga,a   Koichiro Kamoda,a   Ryosuke Kawagoe,a   Akito Tsuruta,a   Shigehiro Ohdoa  and  Akio Ojida ORCID logo *a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
E-mail: ojida@phar.kyushu-u.ac.jp

Abstract

Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, we report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence.

Graphical abstract: Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells

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Article information

DOI
https://doi.org/10.1039/C9CC09993J
Article type
Communication
Submitted
26 Dec 2019
Accepted
05 Feb 2020
First published
05 Feb 2020

Chem. Commun., 2020,56, 3023-3026

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Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells

S. Uchinomiya, N. Matsunaga, K. Kamoda, R. Kawagoe, A. Tsuruta, S. Ohdo and A. Ojida, Chem. Commun., 2020, 56, 3023 DOI: 10.1039/C9CC09993J

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