Application of magnetic Fe3O4 nanoparticles as a reusable heterogeneous catalyst in the synthesis of β-lactams containing amino groups†
Abstract
Herein we report the catalytic activity of magnetic Fe3O4 nanoparticles to promote the reduction of β-lactams containing nitroaryl groups to β-lactams containing aminoaryl groups in ethanol. The catalytic experimental conditions have been optimized to maximize the reaction productivity. This convenient and green catalytic methodology is effective to synthesize aminoaryl-β-lactams containing sustainable groups such as Cl, MeO, alkenyl C![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
C, pyridine rings and β-lactam carbonyl.
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