Issue 36, 2019, Issue in Progress
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RSC Advances

Cobalt(ii)-catalyzed benzylic oxidations with potassium persulfate in TFA/TFAA†

Tianlei Li, ORCID logo ‡a   Jishun Li,‡abc   Zihao Zhu,a   Weidong Pan*b  and  Song Wu*a  

* Corresponding authors

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
E-mail: ws@imm.ac.cn

b State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medcial University, Guiyang 550014, China
E-mail: wdpan@163.com

c Guizhou University of Traditional Chinese Medicine, Huaxi University Town, Guiyang, Guizhou, China

Abstract

A cobalt-catalyzed C(sp3)–H oxygenation reaction to furnish aldehyde was herein reported. This transformation demonstrated high chemo-selectivity, and tolerated various methylarenes bearing electron-withdrawing substituents. This reaction provided rapid access to diverse aldehydes form methylarenes. Notably, TFA/TFAA was used for the first time as a mixed solvent in cobalt-catalyzed oxygenation of benzylic methylenes.

Graphical abstract: Cobalt(ii)-catalyzed benzylic oxidations with potassium persulfate in TFA/TFAA

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Article information

DOI
https://doi.org/10.1039/C9RA03346G
Article type
Paper
Submitted
05 May 2019
Accepted
27 Jun 2019
First published
04 Jul 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 20879-20883

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Cobalt(II)-catalyzed benzylic oxidations with potassium persulfate in TFA/TFAA

T. Li, J. Li, Z. Zhu, W. Pan and S. Wu, RSC Adv., 2019, 9, 20879 DOI: 10.1039/C9RA03346G

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