SCHEDULED MAINTENANCE
Enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines†
Zhouyu
Wang 
*a
and
Xiaomei
Zhang
*ab
*a
and
Xiaomei
Zhang
*ab
Abstract
The first enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines was realized using a chiral phosphoric acid as catalyst. Various novel (bridged) isoxazoline fused dihydrobenzofurans bearing two continuous quaternary stereocenters were achieved in moderate to good yields (up to 94%) with moderate to good enantioselectivities (up to 98% ee). The absolute configurations of two products were assigned by X-ray crystal structural analyses and a plausible reaction mechanism was proposed.
![Graphical abstract: Enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D0CC05807F&imageInfo.ImageIdentifier.Year=2020)
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